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Gene PIK3CA
Variant E453del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA E453del results in the deletion of an amino acid in the C2 PI3K-type domain of the Pik3ca protein at amino acid 453 (UniProt.org). E453del has been identified in sequencing studies (PMID: 35145232, PMID: 31349857, PMID: 26226847), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA E453del

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Transcript NM_006218.4
gDNA chr3:g.179210293_179210295delAGA
cDNA c.1359_1361delAGA
Protein p.E453del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
NM_006218 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA E453del unknown
PIK3CA R88L PIK3CA E453del PIK3CA T1052K PTEN loss PTEN mut