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PIK3CA R93W - Gene Variant Detail

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Gene PIK3CA
Variant R93W
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA R93W lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R93W confers a gain of function on the Pik3ca protein as indicated by in increased phosphorylation of Akt in cell culture (PMID: 21266528) and increased transformation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA R93W

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Transcript NM_006218.4
gDNA chr3:g.179199102C>T
cDNA c.277C>T
Protein p.R93W
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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