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Gene PIK3CA
Variant R93W
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA R93W lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R93W confers a gain of function on the Pik3ca protein as indicated by in increased phosphorylation of Akt in cell culture (PMID: 21266528) and increased transformation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA R93W

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Transcript NM_006218.4
gDNA chr3:g.179199102C>T
cDNA c.277C>T
Protein p.R93W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179199102C>T c.277C>T p.R93W RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199102C>T c.277C>T p.R93W RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199102C>T c.277C>T p.R93W RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199102C>T c.277C>T p.R93W RefSeq GRCh38/hg38
NM_006218 chr3:g.179199102C>T c.277C>T p.R93W RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199102C>T c.277C>T p.R93W RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199102C>T c.277C>T p.R93W RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199102C>T c.277C>T p.R93W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PIK3CA R93W gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor
PIK3CA R93W PIK3CA D350G PTEN R130G