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TP53 Q136L - Gene Variant Detail

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Gene TP53
Variant Q136L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 Q136L lies within the DNA-binding domain and CCAR2, HIPK1, ZNF385A, FBXO42, and AXIN1-interacting regions of the Tp53 protein (UniProt.org). Q136L has been identified in sequencing studies (PMID: 25401301, PMID: 22493262), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 Q136L

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Transcript NM_000546.6
gDNA chr17:g.7675205T>A
cDNA c.407A>T
Protein p.Q136L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_000546 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675205T>A c.407A>T p.Q136L RefSeq GRCh38/hg38

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References