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Gene TP53
Variant L111M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 L111M lies within the DNA-binding domain and the CCAR2, HIPK1, and ZNF385A-interacting region of the Tp53 protein (UniProt.org). L111M has been identified in sequencing studies (PMID: 26933808), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon4 TP53 L111M

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Transcript NM_000546.6
gDNA chr17:g.7676038G>T
cDNA c.331C>A
Protein p.L111M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407262.1 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_000546 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676038G>T c.331C>A p.L111M RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References