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Gene CBL
Variant Y455_D456del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions CBL Y455_D456del results in the deletion of two amino acids of the Cbl protein from amino acids 455 to 456 (UniProt.org). Y455_D456del has been identified in sequencing studies (PMID: 25017477), but has not been biochemically characterized and therefore, its effect on Cbl protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

CBL mutant CBL exon9 CBL Y455_D456del

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Transcript NM_005188.4
gDNA chr11:g.119278645_119278650delTATGAT
cDNA c.1363_1368delTATGAT
Protein p.Y455_D456delYD
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005188 chr11:g.119278645_119278650delTATGAT c.1363_1368delTATGAT p.Y455_D456del RefSeq GRCh38/hg38
XM_011543057 chr11:g.119278645_119278650delTATGAT c.1363_1368delTATGAT p.Y455_D456del RefSeq GRCh38/hg38
NM_005188.4 chr11:g.119278645_119278650delTATGAT c.1363_1368delTATGAT p.Y455_D456delYD RefSeq GRCh38/hg38
NM_005188.3 chr11:g.119278645_119278650delTATGAT c.1363_1368delTATGAT p.Y455_D456del RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries