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Gene DNMT3A
Variant Y528_S535dup
Impact List duplication
Protein Effect unknown
Gene Variant Descriptions DNMT3A Y528_S535dup indicates the insertion of 8 duplicate amino acids, tyrosine (Y)-528 through serine (S)-535 in the ADD domain of the Dnmt3a protein (UniProt.org). Y528_S535dup has not been characterized in the scientific literature and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A Y528_S535dup

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Transcript NM_022552.5
gDNA chr2:g.25244602_25244625
cDNA c.1582_1605
Protein p.Y528_S535
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_175629 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_005264175 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_017003526 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
NM_022552 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_011532664 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25244602_25244625 c.1582_1605 p.Y528_S535 RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References