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Gene ROS1
Variant P151S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 P151S lies within fibronectin type-III domain 1 of the Ros1 protein (UniProt.org). P151S has been identified in sequencing studies (PMID: 27573823, PMID: 26416732), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 P151S

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Transcript NM_002944.3
gDNA chr6:g.117403265G>A
cDNA c.451C>T
Protein p.P151S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_017011172 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_011536051 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_017011173 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117403265G>A c.451C>T p.P151S RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References