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Gene ROS1
Variant L2155S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 L2155S lies within the protein kinase domain of the Ros1 protein (UniProt.org). L2155S has been demonstrated to confer resistance to ROS1 tyrosine kinase inhibitors in the context of a ROS1 fusion in culture (PMID: 25688157), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 L2155S

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Transcript NM_002944.3
gDNA chr6:g.117308899A>G
cDNA c.6464T>C
Protein p.L2155S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.3 chr6:g.117308899A>G c.6464T>C p.L2155S RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117308860_117308861delCTinsAG c.6463_6464delCTinsAG p.L2155S RefSeq GRCh38/hg38
NM_002944 chr6:g.117308899A>G c.6464T>C p.L2155S RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117308860_117308861delCTinsAG c.6463_6464delCTinsAG p.L2155S RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117308899A>G c.6464T>C p.L2155S RefSeq GRCh38/hg38
XM_017011172 chr6:g.117308860_117308861delAGinsCT c.6463_6464delCTinsAG p.L2155S RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References