KIT Y823D
Gene Variant Detail

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Gene KIT
Variant Y823D
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions KIT Y823D lies within the protein kinase domain of the Kit protein (UniProt.org). Y823D confers a gain of function on Kit, as indicated by constitutive phosphorylation of Kit in cultured cells (PMID: 14695343, PMID: 20633291).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT act mut KIT Y823D

KIT mutant KIT exon17 KIT Y823D

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Transcript NM_000222.3
gDNA chr4:g.54733175T>G
cDNA c.2467T>G
Protein p.Y823D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005265741.1 chr4:g.54733175T>G c.2467T>G p.Y823D RefSeq GRCh38/hg38
NM_001385290.1 chr4:g.54733175T>G c.2467T>G p.Y823D RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54733175T>G c.2467T>G p.Y823D RefSeq GRCh38/hg38
NM_000222 chr4:g.54733175T>G c.2467T>G p.Y823D RefSeq GRCh38/hg38
XM_005265741 chr4:g.54733175T>G c.2467T>G p.Y823D RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54733175T>G c.2467T>G p.Y823D RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT Y823D Advanced Solid Tumor sensitive Motesanib Diphosphate Preclinical - Cell culture Actionable In a preclinical study, Motesanib (AMG 706) inhibited KIT phosphorylation and growth of cells expressing KIT Y823D in culture (PMID: 20633291). 20633291
KIT Y823D Advanced Solid Tumor sensitive Nintedanib Preclinical - Cell culture Actionable In a preclinical study, Ofev (nintedanib) inhibited Kit autophosphorylation and proliferation of transformed cells expressing KIT Y823D in culture (PMID: 35194937). 35194937
KIT Y823D melanoma predicted - sensitive Ripretinib Case Reports/Case Series Actionable In a Phase I trial, Qinlock (ripretinib) treatment resulted in a complete response in a patient with metastatic melanoma harboring KIT Y823D (PMID: 35753087; NCT02571036). 35753087
KIT Y823D Advanced Solid Tumor predicted - sensitive IDRX-42 Preclinical - Biochemical Actionable In a preclinical study, IDRX-42 inhibited kinase activity of KIT Y823D in an vitro assay (PMID: 40018846). 40018846