FGFR1 D165_D166del
Gene Variant Detail

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Gene FGFR1
Variant D165_D166del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions FGFR1 D165_D166del (corresponds to D132_D133del in the canonical isoform) results in the deletion of two amino acids in the extracellular domain of the Fgfr1 protein from amino acids 165 to 166 (UniProt.org). D165_D166del has been identified in sequencing studies (PMID: 36142267), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 D165_D166del

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Transcript NM_001174067.2
gDNA chr8:g.38428395_38428400delGTCATC
cDNA c.493_498delGATGAC
Protein p.D165_D166del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017013220.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_047421575.1 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
NM_001174067.1 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_011544452.3 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_011544445.3 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_011544446.3 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_017013219.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_011544447.3 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_011544444.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
NM_001174067.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_017013231.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References