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Gene PIK3CA
Variant N345I
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA N345I lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). N345I results in increased cell survival, but was not transforming in cell culture in one study (PMID: 26627007), but in two other studies, demonstrated increased transformation ability in multiple cell lines compared to wild-type Pik3ca in culture (PMID: 29533785, PMID: 29636477), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA N345I

PIK3CA mutant PIK3CA exon5 PIK3CA N345I

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Transcript NM_006218.4
gDNA chr3:g.179203764A>T
cDNA c.1034A>T
Protein p.N345I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658 chr3:g.179203764A>T c.1034A>T p.N345I RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179203764A>T c.1034A>T p.N345I RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179203764A>T c.1034A>T p.N345I RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179203764A>T c.1034A>T p.N345I RefSeq GRCh38/hg38
XM_011512894 chr3:g.179203764A>T c.1034A>T p.N345I RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179203764A>T c.1034A>T p.N345I RefSeq GRCh38/hg38
NM_006218 chr3:g.179203764A>T c.1034A>T p.N345I RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179203764A>T c.1034A>T p.N345I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA N345I breast cancer resistant Buparlisib Preclinical - Cell culture Actionable In a preclinical study, breast cancer cells expressing PIK3CA N345I demonstrated resistance to treatment with Buparlisib (BKM120) in culture (PMID: 29636477). 29636477