TP53 P278L
Gene Variant Detail

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Gene TP53
Variant P278L
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 P278L lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). P278L results in loss of DNA binding in a reporter assay and decreased activation of Tp53 targets in culture, promotes proliferation and migration, and additionally confers a gain of function to Tp53, resulting in aberrant DNA binding in a reporter assay and transcriptional activation in culture (PMID: 38358025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 P278L

TP53 mutant TP53 inact mut TP53 P278L

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Transcript NM_000546.6
gDNA chr17:g.7673787G>A
cDNA c.833C>T
Protein p.P278L
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.