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TP53 R196* - Gene Variant Detail

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Gene TP53
Variant R196*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 R196* results in a premature truncation of the Tp53 protein at amino acid 196 of 393 (UniProt.org). R196* results in failure to induce apoptosis in Tp53-null cells in culture (PMID: 30840781), and therefore is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 R196*

TP53 mutant TP53 inact mut TP53 R196*

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Transcript NM_000546.6
gDNA chr17:g.7674945G>A
cDNA c.586C>T
Protein p.R196*
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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