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Gene | TP53 |
Variant | V272M |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | TP53 V272M lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). V272M results in increased proliferation, migration, invasion, and protein stability and altered subcellular localization in culture (PMID: 37030635), loss of DNA-binding (PMID: 11870884) and transactivation ability in cell culture (PMID: 11870884, PMID: 22710932). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon8 TP53 V272M TP53 mutant TP53 inact mut TP53 V272M |
Transcript | NM_000546.6 |
gDNA | chr17:g.7673806C>T |
cDNA | c.814G>A |
Protein | p.V272M |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001407264.1 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7673806C>T | c.814G>A | p.V272M | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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