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Gene ROS1
Variant A87T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 A87T lies within the extracellular domain of the Ros1 protein (UniProt.org). A87T has been identified in sequencing studies (PMID: 29338072), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 A87T

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Transcript NM_002944.3
gDNA chr6:g.117409612C>T
cDNA c.259G>A
Protein p.A87T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536051.3 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
NM_002944 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
XM_017011173 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
XM_017011172 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38
XM_011536051 chr6:g.117409612C>T c.259G>A p.A87T RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References