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Gene TP53
Variant E336*
Impact List nonsense
Protein Effect loss of function
Gene Variant Descriptions TP53 E336* results in a premature truncation of the Tp53 protein at amino acid 336 of 393 (UniProt.org). E336* results in decreased Tp53 transactivation activity and reduced nuclear localization in cell culture (PMID: 9331090, PMID: 16969106).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 E336*

TP53 mutant TP53 inact mut TP53 E336*

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Transcript NM_000546.6
gDNA chr17:g.7670703C>A
cDNA c.1006G>T
Protein p.E336*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38
NM_000546 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38
NM_001126112 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670703C>A c.1006G>T p.E336* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 E336* loss of function p53 Gene Therapy