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Gene | TP53 |
Variant | M237I |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | TP53 M237I lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). M237I results in decreased DNA binding and Tp53 transactivation activity, resistance to apoptosis, failure of G1 arrest in cell culture (PMID: 16492679, PMID: 20080630, PMID: 31395785), increased colony formation compared to wild-type in the presence of an MDM2 antagonist in cell culture, and tumor growth in mouse models (PMID: 35165384). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon7 TP53 M237I TP53 mutant TP53 inact mut TP53 M237I |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674252C>G |
cDNA | c.711G>C |
Protein | p.M237I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001407270.1 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7674252C>G | c.711G>C | p.M237I | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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