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TP53 M237I - Gene Variant Detail

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Gene TP53
Variant M237I
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 M237I lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). M237I results in decreased DNA binding and Tp53 transactivation activity, resistance to apoptosis, failure of G1 arrest in cell culture (PMID: 16492679, PMID: 20080630, PMID: 31395785), increased colony formation compared to wild-type in the presence of an MDM2 antagonist in cell culture, and tumor growth in mouse models (PMID: 35165384).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 M237I

TP53 mutant TP53 inact mut TP53 M237I

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Transcript NM_000546.6
gDNA chr17:g.7674252C>G
cDNA c.711G>C
Protein p.M237I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_000546 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674252C>G c.711G>C p.M237I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 M237I high grade glioma sensitive AZ32 + Radiotherapy Preclinical - Cell culture Actionable In a preclinical study, AZ32 treatment increased sensitivity to radiotherapy in malignant glioma cells harboring TP53 M237I in culture, resulting in a greater decrease in cell survival compared to radiation treatment alone (PMID: 29769307). 29769307
TP53 M237I high grade glioma sensitive KU-60019 + Radiotherapy Preclinical - Cell culture Actionable In a preclinical study, KU-60019 treatment increased sensitivity to radiotherapy in malignant glioma cells harboring TP53 M237I in culture, resulting in a greater decrease in cell survival compared to radiation treatment alone (PMID: 29769307). 29769307