FGFR1 V561M
Gene Variant Detail

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Gene FGFR1
Variant V561M
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR1 V561M lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). V561M results in increased Fgfr1 autophosphorylation (PMID: 25686244), increased Stat3 phosphorylation and STAT3-dependent gene expression, elevated expression of mesenchymal genes, and increased migration (PMID: 30257990), cell proliferation, and anchorage-independent growth in culture (PMID: 30257990, PMID: 40526877), and has been shown to be associated with resistance to tyrosine kinase inhibitors (PMID: 25686244, PMID: 40526877, PMID: 28646488),
Associated Drug Resistance Y
Category Variants Paths

FGFR1 mutant FGFR1 act mut FGFR1 V561M

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Transcript NM_023110.3
gDNA chr8:g.38416043C>T
cDNA c.1681G>A
Protein p.V561M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
NM_023110 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
XM_017013221 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38
XM_006716303 chr8:g.38416043C>T c.1681G>A p.V561M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
FGFR1 V561M gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor