Gene Variant Detail

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Gene ATM
Variant S707P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATM S707P does not lie within any known functional domains of the Atm protein (UniProt.org). S707P has been associated with a modest increased risk of breast cancer (PMID: 20826828), and results in decreased Atm protein expression in cultured cells (PMID: 31664505), but has not been fully biochemically characterized and therefore, its effect on Atm protein function is unknown.
Associated Drug Resistance
Category Variants Paths

ATM mutant ATM S707P

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Transcript NM_000051.4
gDNA chr11:g.108254034T>C
cDNA c.2119T>C
Protein p.S707P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006718843.4 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_005271562.6 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017791 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
NM_000051 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_047426981.1 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_011542843.2 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017789.2 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_047426975.1 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_006718843.5 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017789 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017790.2 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_011542843.3 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
NM_000051.4 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_006718843 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_005271561 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
NM_000051.3 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017792.2 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_011542843 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_011542840 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_047426976.1 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_011542840.3 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_011542840.4 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
NM_001351834.1 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017790 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
NM_001351834.2 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017792 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_005271562 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017791.1 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_005271562.5 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38
XM_017017790.3 chr11:g.108254034T>C c.2119T>C p.S707P RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References