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Gene ROS1
Variant I537M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 I537M lies within the extracellular domain of the Ros1 protein (UniProt.org). I537M has been identified in sequencing studies (PMID: 31346352, PMID: 18056464), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 I537M

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Transcript NM_002944.3
gDNA chr6:g.117389498T>C
cDNA c.1611A>G
Protein p.I537M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_017011173 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_017011172 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_011536051 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117389498T>C c.1611A>G p.I537M RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries