CHEK1 T226Hfs*14
Gene Variant Detail

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Gene CHEK1
Variant T226Hfs*14
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions CHEK1 T226Hfs*14 indicates a shift in the reading frame starting at amino acid 226 and terminating 14 residues downstream causing a premature truncation of the 476 amino acid Chek1 protein (UniProt.org). T226Hfs*14 has been identified in sequencing studies (PMID: 38957326, PMID: 39398648, PMID: 41100773), but has not been biochemically characterized and therefore, its effect on Chek1 protein function is unknown (PubMed, May 2026).
Associated Drug Resistance
Category Variants Paths

CHEK1 mutant CHEK1 T226Hfs*14

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Transcript NM_001114122.3
gDNA chr11:g.125635491delA
cDNA c.676delA
Protein p.T226Hfs*14
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001244846 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001114122 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001114121.2 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001244846.1 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001274.5 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001114121.2 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001114122.2 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
XM_024448337.2 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001274.5 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001114121 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001274 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
XM_017017146.2 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
XM_024448337.1 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001244846.1 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
XM_017017146 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
NM_001114122.3 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38
XM_047426311.1 chr11:g.125635491delA c.676delA p.T226Hfs*14 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
CHEK1 T226Hfs*14 unknown