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Gene CHEK1
Variant E223_T226delinsA
Impact List indel
Protein Effect unknown
Gene Variant Descriptions CHEK1 E223_T226delinsA results in a deletion of four amino acids from aa 223 to 226 within the protein kinase domain of the Chek1 protein, combined with the insertion of an Alanine (A) at the same site (UniProt.org). E223_T226delinsA has not been characterized in the scientific literature and therefore, its effect on Chek1 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

CHEK1 mutant CHEK1 E223_T226delinsA

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Transcript NM_001114121.2
gDNA chr11:g.125635483_125635491delAAAAAAAAA
cDNA c.668_676delAAAAAAAAA
Protein p.E223_T226delinsA
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024448337.2 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
XM_017017146 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
XM_047426311.1 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001274.5 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001114122.3 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001244846 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001114122 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001244846.1 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
XM_017017146.2 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001114121.2 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001114122.2 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001244846.1 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001114121.2 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001274.5 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001274 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
NM_001114121 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38
XM_024448337.1 chr11:g.125635483_125635491delAAAAAAAAA c.668_676delAAAAAAAAA p.E223_T226delinsA RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References