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Gene CHEK1
Variant D235Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CHEK1 D235Y lies within the protein kinase domain of the Chek1 protein (UniProt.org). D235Y has been identified in sequencing studies (PMID: 22510280), but has not been biochemically characterized and therefore, its effect on Chek1 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

CHEK1 mutant CHEK1 D235Y

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Transcript NM_001114121.2
gDNA chr11:g.125635518G>T
cDNA c.703G>T
Protein p.D235Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011542563 chr11:g.125644152G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001244846 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001330428.1 chr11:g.125644152G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001114121.2 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
XM_024448337.2 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
XM_047426313.1 chr11:g.125644152G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001244846.1 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
XM_017017146.2 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
XM_024448337.1 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001114121.2 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001114122.2 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
XM_047426311.1 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001114122 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
XM_017017146 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001274.5 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001330427.2 chr11:g.125644173G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001274.5 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001114122.3 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001114121 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001274 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001244846.1 chr11:g.125635518G>T c.703G>T p.D235Y RefSeq GRCh38/hg38
NM_001330428.1 chr11:g.125644152G>T c.703G>T p.D235Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References