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Gene TP53
Variant S33A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 S33A lies within the CCAR2 and HRMT1L2-interacting regions and the transcription activation region of the Tp53 protein (UniProt.org). S33A demonstrates Slk-stimulated transcriptional activity similar to wild-type Tp53 in culture in one study (PMID: 19640899), but decreased transcriptional response to CDDP in another study (PMID: 10811125) and loss of FBW7a-binding and ubiquitination, preventing degradation in cell lines (PMID: 31346036), and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon4 TP53 S33A

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Transcript NM_000546.6
gDNA chr17:g.7676272A>C
cDNA c.97T>G
Protein p.S33A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_000546 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7676272A>C c.97T>G p.S33A RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 S33A unknown