Gene Variant Detail

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Gene TP53
Variant K24I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 K24I lies within the CCAR2 and HRMT1L2-interacting and transcription activation regions of the Tp53 protein (UniProt.org). K24I has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon2 TP53 K24I

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Transcript NM_000546.6
gDNA chr17:g.7676524T>A
cDNA c.71A>T
Protein p.K24I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_000546 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676524T>A c.71A>T p.K24I RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References