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| Gene | STK11 |
| Variant | W332* |
| Impact List | nonsense |
| Protein Effect | unknown |
| Gene Variant Descriptions | STK11 W332* results in a premature truncation of the Stk11 protein at amino acid 332 of 433 (UniProt.org). W332* has been identified in sequencing studies (PMID: 17711506, PMID: 27923066, PMID: 28978051), but has not been biochemically characterized and therefore, its effect on Stk11 protein function is unknown (PubMed, Oct 2025). |
| Associated Drug Resistance | |
| Category Variants Paths |
STK11 mutant STK11 W332* |
| Transcript | NM_000455.5 |
| gDNA | chr19:g.1223059G>A |
| cDNA | c.995G>A |
| Protein | p.W332* |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_001407255.1 | chr19:g.1223059G>A | c.995G>A | p.W332* | RefSeq | GRCh38/hg38 |
| XM_005259618 | chr19:g.1223059G>A | c.995G>A | p.W332* | RefSeq | GRCh38/hg38 |
| XM_005259617.3 | chr19:g.1223059G>A | c.995G>A | p.W332* | RefSeq | GRCh38/hg38 |
| NM_000455 | chr19:g.1223059G>A | c.995G>A | p.W332* | RefSeq | GRCh38/hg38 |
| NM_000455.5 | chr19:g.1223059G>A | c.995G>A | p.W332* | RefSeq | GRCh38/hg38 |
| XM_005259617 | chr19:g.1223059G>A | c.995G>A | p.W332* | RefSeq | GRCh38/hg38 |
| NM_000455.4 | chr19:g.1223059G>A | c.995G>A | p.W332* | RefSeq | GRCh38/hg38 |
| XM_005259618.3 | chr19:g.1223059G>A | c.995G>A | p.W332* | RefSeq | GRCh38/hg38 |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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