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NRAS E63K - Gene Variant Detail

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Gene NRAS
Variant E63K
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NRAS E63K does not lie within any known functional domains of the Nras protein (UniProt.org). E63K confers a loss of function on Nras protein as demonstrated by increased GTP-bound Nras leading to activation of downstream signaling, and is associated with resistance to Egfr inhibitors in culture (PMID: 25870145).
Associated Drug Resistance Y
Category Variants Paths

NRAS mutant NRAS act mut NRAS E63K

NRAS mutant NRAS exon3 NRAS E63K

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Transcript NM_002524.5
gDNA chr1:g.114713903C>T
cDNA c.187G>A
Protein p.E63K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713903C>T c.187G>A p.E63K RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713903C>T c.187G>A p.E63K RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713903C>T c.187G>A p.E63K RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References