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Gene TP53
Variant V272A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 V272A lies within the DNA-binding domain of the Tp53 protein (UniProt.org). V272A results in increased expression of Tp53 in an in vitro assay (PMID: 28363997), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 V272A

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Transcript NM_000546.6
gDNA chr17:g.7673805A>G
cDNA c.815T>C
Protein p.V272A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.5 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_000546 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673805A>G c.815T>C p.V272A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
TP53 V272A unknown