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Gene MSH6
Variant G624S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 G624S lies within the connector domain of the Msh6 protein (PMID: 17531815). G624S has been identified in sequencing studies (PMID: 21097718, PMID: 32095738), but has not been biochemically characterized and therefore, its effect on Msh6 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 G624S

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Transcript NM_000179.3
gDNA chr2:g.47799853G>A
cDNA c.1870G>A
Protein p.G624S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406828.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
XM_011532798 chr2:g.47800036G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
XM_024452820.1 chr2:g.47800036G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406830.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406825.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406805.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406822.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406804.1 chr2:g.47799931G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406821.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406820.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406824.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
XM_011532799 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406797.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406819.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406803.1 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
XM_024452821.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406827.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406818.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_000179 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47799853G>A c.1870G>A p.G624S RefSeq GRCh38/hg38
NM_001406801.1 chr2:g.47800150G>A c.1870G>A p.G624S RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References