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Gene MSH6
Variant K185T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 K185T does not lie within any known functional domains of the Msh6 protein (UniProt.org). K185T has been identified in sequencing studies (PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Msh6 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 K185T

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Transcript NM_000179.3
gDNA chr2:g.47795990A>C
cDNA c.554A>C
Protein p.K185T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406796.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
XM_024452820.1 chr2:g.47798720A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_001406817.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
XM_011532798 chr2:g.47798720A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_001407362.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_001406803.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_000179 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47795990A>C c.554A>C p.K185T RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References