MSH6 S314I
Gene Variant Detail

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Gene MSH6
Variant S314I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 S314I does not lie within any known functional domains of the Msh6 protein (UniProt.org). S314I is predicted to have no impact on Msh6 protein function by computational analysis (PMID: 23621914), but has not been biochemically characterized and therefore, its effect on Msh6 protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 S314I

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Transcript NM_000179.3
gDNA chr2:g.47798924G>T
cDNA c.941G>T
Protein p.S314I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001281493.2 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001406811.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001281493 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001406829.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
XM_024452822.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001406823.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001281493.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001406815.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001406817.1 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001406816.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001281494.2 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_000179 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001281494 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001406814.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001406803.1 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001281494.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
NM_001406812.1 chr2:g.47799829_47799830delTCinsAT c.940_941delTCinsAT p.S314I RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47798924G>T c.941G>T p.S314I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References