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Gene MSH6
Variant T269S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 T269S does not lie within any known functional domains of the Msh6 protein (UniProt.org). T269S is predicted to have no impact on Msh6 protein function by computational analysis (PMID: 23621914), but has not been biochemically characterized and therefore, its effect on Msh6 protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 T269S

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Transcript NM_000179.3
gDNA chr2:g.47798789C>G
cDNA c.806C>G
Protein p.T269S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000179.3 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_001406803.1 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_000179 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_001406817.1 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47798789C>G c.806C>G p.T269S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References