MSH6 P1087R
Gene Variant Detail

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Gene MSH6
Variant P1087R
Impact List missense
Protein Effect no effect
Gene Variant Descriptions MSH6 P1087R lies within the ATPase domain of the Msh6 protein (PMID: 17531815). P1087R demonstrates binding to Msh2, in vitro mismatch repair activity (PMID: 12019211, PMID: 21120944), and subcellular localization similar to wild-type Msh6 in culture (PMID: 22851212).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 P1087R

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Transcript NM_000179.3
gDNA chr2:g.47803507C>G
cDNA c.3260C>G
Protein p.P1087R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024452819.1 chr2:g.47803507C>G c.3260C>G p.P1087R RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47803507C>G c.3260C>G p.P1087R RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47803507C>G c.3260C>G p.P1087R RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47803507C>G c.3260C>G p.P1087R RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47803507C>G c.3260C>G p.P1087R RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47803507C>G c.3260C>G p.P1087R RefSeq GRCh38/hg38
NM_000179 chr2:g.47803507C>G c.3260C>G p.P1087R RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47803507C>G c.3260C>G p.P1087R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References