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Gene IDH2
Variant F394I
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions IDH2 F394I does not lie within any known functional domains of the Idh2 protein (UniProt.org). F394I results in decreased cellular accumulation of Idh2 protein in culture (PMID: 21996744), and therefore, is predicted to lead to a loss of Idh2 protein function.
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 inact mut IDH2 F394I

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Transcript NM_002168.4
gDNA chr15:g.90084907A>T
cDNA c.1180T>A
Protein p.F394I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168.3 chr15:g.90084907A>T c.1180T>A p.F394I RefSeq GRCh38/hg38
NM_002168 chr15:g.90084907A>T c.1180T>A p.F394I RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90084907A>T c.1180T>A p.F394I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References