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Gene TP53
Variant T140I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 T140I lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). T140I is predicted to destabilize the S6-S7 loop by structural modeling (PMID: 35659507), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Sep 2023).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 T140I

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Transcript NM_000546.6
gDNA chr17:g.7675193G>A
cDNA c.419C>T
Protein p.T140I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.2 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_000546 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675193G>A c.419C>T p.T140I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 T140I unknown