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Gene TP53
Variant P142L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 P142L lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). P142L is unable to transactivate reporter genes in yeast assays (PMID: 17311302), and results in interaction with Tbk1 leading to decreased Tbk1 and Irf3 phosphorylation and loss of Irf3 activation in culture (PMID: 33545063), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 P142L

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Transcript NM_000546.6
gDNA chr17:g.7675187G>A
cDNA c.425C>T
Protein p.P142L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.2 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276697.3 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276698.3 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276698.1 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276697.1 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276697 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276699.1 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276699.3 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_000546 chr17:g.7675187G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276698 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38
NM_001276699 chr17:g.7673718G>A c.425C>T p.P142L RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 P142L unknown