FLT3 D835F
Gene Variant Detail

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Gene FLT3
Variant D835F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 D835F lies within the activation loop in the protein kinase domain of the Flt3 protein (PMID: 25837374). D835F has been associated with FLT3 inhibitor resistance (PMID: 24227820, PMID: 23430109), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 D835X FLT3 D835F

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Transcript NM_004119.3
gDNA chr13:g.28018504_28018505delGAinsTT
cDNA c.2503_2504delGAinsTT
Protein p.D835F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018504_28018505delGAinsTT c.2503_2504delGAinsTT p.D835F RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018504_28018505delGAinsTT c.2503_2504delGAinsTT p.D835F RefSeq GRCh38/hg38
NM_004119 chr13:g.28018504_28018505delTCinsAA c.2503_2504delGAinsTT p.D835F RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 D835F hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, Xospata (gilteritinib) resulted in reduced cell viability in transformed cells expressing FLT3 D835F in culture (PMID: 32040554). 32040554