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FLT3 Y842H - Gene Variant Detail

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Gene FLT3
Variant Y842H
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 Y842H lies within the protein kinase domain of the Flt3 protein (UniProt.org). Y842H results in increased phosphorylation of Flt3, activation of Stat5 and Mapk, and transformation of cultured cells (PMID: 14604974), and is associated with acquired resistance in the context of FLT3-ITD (PMID: 25847190, PMID: 22504184, PMID: 29187377).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 Y842H

FLT3 mutant FLT3 exon20 FLT3 Y842H

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Transcript NM_004119.3
gDNA chr13:g.28018484A>G
cDNA c.2524T>C
Protein p.Y842H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018484A>G c.2524T>C p.Y842H RefSeq GRCh38/hg38
NM_004119 chr13:g.28018484A>G c.2524T>C p.Y842H RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018484A>G c.2524T>C p.Y842H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References