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Gene FLT3
Variant D839H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 D839H lies within the protein kinase domain of the Flt3 protein (UniProt.org). D839H has been demonstrated to occur as a secondary resistance mutation in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 25847190), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, May 2024).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 D839H

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Transcript NM_004119.3
gDNA chr13:g.28018493C>G
cDNA c.2515G>C
Protein p.D839H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018493C>G c.2515G>C p.D839H RefSeq GRCh38/hg38
NM_004119 chr13:g.28018493C>G c.2515G>C p.D839H RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018493C>G c.2515G>C p.D839H RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References