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Gene TP53
Variant N235D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 N235D lies within the DNA binding domain and the HIPK1, ZNF385A, FBXO42 and AXIN1 interaction region of the Tp53 protein (UniProt.org). N235D results in decreased Tp53 transactivation activity and fails to suppress colony formation in cell culture (PMID: 25584008).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 N235D

TP53 mutant TP53 inact mut TP53 N235D

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Transcript NM_000546.6
gDNA chr17:g.7674260T>C
cDNA c.703A>G
Protein p.N235D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_000546 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674260T>C c.703A>G p.N235D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References