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Gene | TP53 |
Variant | P177A |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 P177A lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). P177A has been identified in the scientific literature (PMID: 29979965, PMID: 30337457), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2025). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon5 TP53 P177A |
Transcript | NM_000546.6 |
gDNA | chr17:g.7675083G>C |
cDNA | c.529C>G |
Protein | p.P177A |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |