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TP53 A161V - Gene Variant Detail

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Gene TP53
Variant A161V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 A161V lies within the DNA-binding domain of the Tp53 protein (PMID: 21232794). A161V does not result in decreased drug-induced apoptosis compared to wild-type Tp53 (PMID: 12726864), and results in interaction with Tbk1 and decreased Tbk1 and Irf3 phosphorylation and loss of Irf3 activation in culture (PMID: 33545063), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 A161V

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Transcript NM_000546.6
gDNA chr17:g.7675130G>A
cDNA c.482C>T
Protein p.A161V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.2 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_000546 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675130G>A c.482C>T p.A161V RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References