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Gene FLT3
Variant D839A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 D839A lies within the activation loop in the protein kinase domain of the Flt3 protein (PMID: 25837374). D839A has been demonstrated to occur as a secondary resistance mutation in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 25847190), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 D839A

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Transcript NM_004119.3
gDNA chr13:g.28018492T>G
cDNA c.2516A>C
Protein p.D839A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018492T>G c.2516A>C p.D839A RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018492T>G c.2516A>C p.D839A RefSeq GRCh38/hg38
NM_004119 chr13:g.28018492T>G c.2516A>C p.D839A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
FLT3 D839A unknown
FLT3 exon 14 ins FLT3 D839A
FLT3 exon 14 ins FLT3 F691L FLT3 D839A