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FLT3 D839N - Gene Variant Detail

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Gene FLT3
Variant D839N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 D839N lies within the activation loop of the protein kinase domain of the Flt3 protein (PMID: 25837374). D839N has been demonstrated to occur as a secondary resistance mutation in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 25847190), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2025).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 D839N

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Transcript NM_004119.3
gDNA chr13:g.28018493C>T
cDNA c.2515G>A
Protein p.D839N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28018493C>T c.2515G>A p.D839N RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018493C>T c.2515G>A p.D839N RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018493C>T c.2515G>A p.D839N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References