FLT3 M664I
Gene Variant Detail

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Gene FLT3
Variant M664I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 M664I lies within the protein kinase domain of the Flt3 protein (UniProt.org). M664I has been demonstrated to occur as a secondary resistance mutation in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 25847190), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon16 FLT3 M664I

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Transcript NM_004119.3
gDNA chr13:g.28028239C>G
cDNA c.1992G>C
Protein p.M664I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28028239C>G c.1992G>C p.M664I RefSeq GRCh38/hg38
NM_004119 chr13:g.28028239C>G c.1992G>C p.M664I RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28028239C>G c.1992G>C p.M664I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FLT3 M664I unknown
FLT3 exon 14 ins FLT3 M664I
FLT3 exon 14 ins FLT3 M664I FLT3 F691L