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Gene FLT3
Variant Y842S
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 Y842S lies within the activation loop of the protein kinase domain of the Flt3 protein (PMID: 25837374). Y842S has been demonstrated to occur as a secondary resistance mutation in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 25847190), and results in increased catalytic activity and autophosphorylation of the Flt3 kinase domain in in vitro assays, and therefore, is predicted to lead to a gain of Flt3 protein function (PMID: 31943770).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 Y842S

FLT3 mutant FLT3 exon20 FLT3 Y842S

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Transcript NM_004119.3
gDNA chr13:g.28018483T>G
cDNA c.2525A>C
Protein p.Y842S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018483T>G c.2525A>C p.Y842S RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018483T>G c.2525A>C p.Y842S RefSeq GRCh38/hg38
NM_004119 chr13:g.28018483T>G c.2525A>C p.Y842S RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References