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PIK3CA P449T - Gene Variant Detail

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Gene PIK3CA
Variant P449T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA P449T lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). P449T results in increased Pik3ca kinase activity in cell culture (PMID: 20530683), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA P449T

PIK3CA mutant PIK3CA exon8 PIK3CA P449T

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Transcript NM_006218.4
gDNA chr3:g.179210279C>A
cDNA c.1345C>A
Protein p.P449T
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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