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Gene TP53
Variant P223L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 P223L lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). The functional effect of P223L is conflicting, as it results in DNA-binding, cellular senescence, expression of Tp53 targets, and acetylation of Tp53 similar to wild-type Tp53 in culture in one study (PMID: 27911860), however, in another study, demonstrates decreased Tp53 transactivation and reduced expression of the Tp53 target p21 in culture (PMID: 16741917), and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 P223L

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Transcript NM_000546.6
gDNA chr17:g.7674863G>A
cDNA c.668C>T
Protein p.P223L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38
NM_000546 chr17:g.7674863G>A c.668C>T p.P223L RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 P223L unknown
TP53 P223L TP53 V274F